A Combinatory Approach for Selecting Prognostic Genes in Microarray Studies of Tumour Survivals
نویسندگان
چکیده
منابع مشابه
A Combinatory Approach for Selecting Prognostic Genes in Microarray Studies of Tumour Survivals
Different from significant gene expression analysis which looks for genes that are differentially regulated, feature selection in the microarray-based prognostic gene expression analysis aims at finding a subset of marker genes that are not only differentially expressed but also informative for prediction. Unfortunately feature selection in literature of microarray study is predominated by the ...
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High throughput technologies, such as gene expression arrays and protein mass spectrometry, allow one to simultaneously evaluate thousands of potential biomarkers that could distinguish different tissue types. Of particular interest here is distinguishing between cancerous and normal organ tissues. We consider statistical methods to rank genes (or proteins) in regards to differential expression...
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Motivation: Recent studies have shown that microarray gene expression data is useful for phenotype classification of many diseases. In this classification problem, the number of features (genes) greatly exceeds the number of instances (tissue samples). It has been shown that selecting a small set of informative genes can lead to improved classification accuracy. Many approaches have been propos...
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ژورنال
عنوان ژورنال: Advances in Bioinformatics
سال: 2009
ISSN: 1687-8027,1687-8035
DOI: 10.1155/2009/480486